KMID : 0369820130430040279
|
|
Jorunal of Korean Pharmaceutical Sciences 2013 Volume.43 No. 4 p.279 ~ p.285
|
|
Solubility modulation of bicalutamide using porous silica
|
|
Meer Tarique
Fule Ritesh Khanna Deepak Amin Purnima
|
|
Abstract
|
|
|
Objective of the present study was to explore the potential of porous silica (AEROPERL¢ç 300 Pharma) in modulating dissolution kinetics of poorly water soluble drug bicalutamide (BCL). The drug release from the developed formulation was found to be significantly higher as compared to neat BCL. This improved release kinetics of BCL may be attributed to high surface area, improved wettability and decreased crystallinity. Solid state characterization of the developed formulation was carried out with respect to IR, XRPD, SEM, DSC and dissolution. The proposed system showed a significant capability for the solubility enhancement of BCL. The dissolution profile from BCL-AEROPERL¢ç 300 Pharma (AP) system was fitted into various drug release kinetics models, in order to understand the BCL release mechanism.
|
|
KEYWORD
|
|
Bicalutamide, Porous silica, Dissolution rate enhancement, BCS class II
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|